Though the two processes are conceptually separate, they are mutually cooperative i.e one can lead to the other. In either case, talin binding to the integrin tails is an essential and the final common step ( 10, reviewed in 11 ). This low affinity structure undergoes rapid, reversible conformational changes to increase ligand affinity, termed activation (reviewed in 5 6 7 ). Integrin Activation Pmanet Ilwu Free Diffusing IntegrinsĬrystal structures have revealed that integrin heterodimers, occur in an inactive, bent V-shape with the head close to the membrane-proximal regions of the legs 2 3, maintained by the salt bridge at the inner membrane region and helix packing of the transmembrane (TM) region 4.
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